Reported outcomes
Not one adverse event occurred among these residents and staff and no hospitalizations were necessary either.
All of our patients evolved satisfactorily and were recovered at the beginning of June. No adverse effects were recorded in any patient and no one required hospital admission. At the end of June, 100% of the residents and almost half of the workers had positive serology for COVID-19, most of them with past infection.
Between March and April 2020, 84 elderly patients with suspected COVID-19 living in two nursing homes of Yepes, Toledo (Spain) were treated early with antihistamines (dexchlorpheniramine, cetirizine or loratadine), adding azithromycin in the 25 symptomatic cases. The outcomes are retrospectively reported. The primary endpoint is the fatality rate of COVID-19. The secondary endpoints are the hospital and ICU admission rates. Endpoints were compared with the official Spanish rates for the elderly. The mean age of our population was 85 and 48% were over 80 years old. No hospital admissions, deaths, nor adverse drug effects were reported in our patient population. By the end of June, 100% of the residents had positive serology for COVID-19. Although clinical trials are needed to determine the efficacy of both drugs in the treatment of COVID-19, this analysis suggests that primary care diagnosis and treatment with antihistamines, plus azithromycin in selected cases, may treat COVID-19 and prevent progression to severe disease in elderly patients.
Sources:
Antihistamines and azithromycin as a treatment for COVID-19 on primary health care – A retrospective observational study in elderly patients, National Institutes of Health, 2021 Apr; 67: 101989. Published online 2021 Jan 16.
Once Upon A Time…, 2021-09-24 05:03 by Karl Denninger in Covid-19 , 386 references
What did these few nursing homes did:
- 1. Early start of treatment, regardless of the severity of patient symptoms.
- – Antihistamines every 12 h: dexchlorpheniramine 2 mg, cetirizine 10 mg or loratadine 10 mg.
- – Azithromycin 500 mg orally every 24 h for 3 days if there is rapid improvement, and for 6 days if the duration of symptoms is prolonged.
- – If pain or fever, acetaminophen 650 mg/6–8 h.
- – Nasal washing and gargling with sodium bicarbonate water (half a glass of warm water with half a teaspoon of sodium bicarbonate).
- 2. Patients with mild or recent-onset symptoms (cough, fever, general malaise, anosmia, polymyalgia):
- – Antihistamines + Azithromycin (see mild treatment management)
- – Levofloxacin 500 mg/12 h, up to 14 days of antibiotic treatment from diagnosis.
- – Mepifilin solution, 50 mg/8 h as a bronchodilator, until subjective improvement. Patients with previous lung disease (asthma or COPD) used their usual bronchodilators.
- – If the patient experienced increased breathing difficulty, prednisone 1 mg/kg/day divided into two doses until clinical improvement, and then it was slowly tapered down.
- 3. If symptoms of severity (dyspnea, breathing difficulty, mild or moderate chest pain, with SpO2 >80%, heart rate <100 beats per minute at any time of the process).
- 4. Prophylactic treatment for close contacts, including all asymptomatic residents:
- – Antihistamines at the same dose as symptomatic patients.
Cetrizine is otherwise known as Zyrtec. Loratadine is otherwise known as Claritin. Dexchlorpheniramine is not often-used in the US anymore, but it used to be. The other two core drugs were Azithromycin and Levofloxacin, both common antibiotics with the first being the infamous “Zpak” from the HCQ+Zinc+Zpak combination that a fraudulent study was used to discredit.
Both of the first two antihistamines are available over the counter in most nations including the United States. The dosing they used is twice that on the label. The two antibiotics are both available anywhere for little money.
RESULTS
Before they started treating people three residents died. The entire group of them had the common maladies of old age — hypertension, diabetes, COPD, cardiovascular disease. Most were using a huge range of existing drugs for their conditions (5 or more.)
As soon as they started treating people the following happened:
All of our patients evolved satisfactorily and were recovered at the beginning of June. No adverse effects were recorded in any patient and no one required hospital admission. At the end of June, 100% of the residents and almost half of the workers had positive serology for COVID-19, most of them with past infection.
Not one adverse event occurred among these residents and staff and no hospitalizations were necessary either.
In pooled data 28% of the residents in similar nursing homes over the same time period died. In these two, once they started treating with cheap drugs, leading with those available over the counter in the US, ZERO — I repeat — ZERO had a bad reaction to the protocol, ZERO died and ZERO were admitted to a hospital for treatment.
ZERO.
It was one hundred percent effective.